Piedmont is a fourth-class city located in northwestern Wayne County in Southeast Missouri in the United States. The population was 1,977 at the 2010 census. A part of the Ozarks Foothills Region, Piedmont is located on the convergence of State Highways 34 and 49. Piedmont, transliterated as "foot of the mountain," is named for its geographic placement at the foot of Clark Mountain, a 1424-foot summit approximately two miles north of the town.